GPC2

Description		glypican 2
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Side Of Membrane
	Molecular Function	Protein Binding
	Biological Process	Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Neuron Differentiation Regulation Of Protein Localization To Membrane
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		1 novel interacting genes: PTPRS
Interacting Genes		1 interacting genes: PTPRS
Entrez ID		221914
HPRD ID		17051
Ensembl ID		ENSG00000213420
Uniprot IDs		Q8N158
PDB IDs		6WJL 7T62
Enriched GO Terms of Interacting Partners?		Regulation Of Collateral Sprouting Corpus Callosum Development Regulation Of Toll-like Receptor 9 Signaling Pathway Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Interferon-beta Production Negative Regulation Of Collateral Sprouting Regulation Of Postsynaptic Specialization Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Postsynaptic Density Assembly Negative Regulation Of Axon Regeneration Negative Regulation Of Interferon-alpha Production Heparan Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Negative Regulation Of Neuron Projection Regeneration Regulation Of Excitatory Synapse Assembly Negative Regulation Of Dendritic Spine Development Synaptic Membrane Adhesion Spinal Cord Development Regulation Of Neuron Projection Regeneration Negative Regulation Of Axon Extension Regulation Of Axon Regeneration Establishment Of Endothelial Barrier Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Endothelial Cell Development Negative Regulation Of Type I Interferon Production Cerebellum Development Negative Regulation Of Axonogenesis Regulation Of Dendritic Spine Development Regulation Of Interferon-beta Production Hippocampus Development Cerebral Cortex Development Protein Dephosphorylation Regulation Of Axon Extension Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Negative Regulation Of Developmental Growth Postsynaptic Density Membrane Perikaryon Epithelial Cell Development Growth Cone Regulation Of Postsynapse Organization Negative Regulation Of Nervous System Development Regulation Of Type I Interferon Production Regulation Of Axonogenesis Dephosphorylation Presynaptic Membrane Synaptic Vesicle Membrane Negative Regulation Of Neurogenesis
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