FCGR3B

Description		Fc gamma receptor IIIb
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	IgG Receptor Activity IgG Binding GPI Anchor Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Immune Response Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Muromonab Alemtuzumab Alefacept Natalizumab Palivizumab Daclizumab Catumaxomab Sarilumab
Diseases		Systemic lupus erythematosus
GWAS		Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Blood protein levels ( 30072576) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233 28067908) Limited cutaneous systemic scleroderma ( 29293537) Monocyte count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Novel Interacting Genes		2 novel interacting genes: APCS IGHG1
Interacting Genes		2 interacting genes: APCS IGHG1
Entrez ID		2215
HPRD ID		09951
Ensembl ID		ENSG00000162747
Uniprot IDs		A0A3B3ISU3 H0Y4U3 O75015
PDB IDs		1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?		Acute Inflammatory Response Blood Microparticle Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Negative Regulation Of Monocyte Differentiation Complement Component C1q Complex Binding Inflammatory Response Antibody-dependent Cellular Cytotoxicity IgG Immunoglobulin Complex Immunoglobulin Complex, Circulating Virion Binding Hypersensitivity Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Glycoprotein Metabolic Process Defense Response To Other Organism Host-mediated Suppression Of Viral Proces Defense Response To Symbiont Immunoglobulin Receptor Binding Acute Inflammatory Response To Antigenic Stimulus Regulation Of Monocyte Differentiation Immunoglobulin Complex Chaperone-mediated Protein Complex Assembly Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Antigen Binding Complement Activation, Classical Pathway Inflammatory Response To Antigenic Stimulus Acute-phase Response Immunoglobulin Mediated Immune Response Immune Response Defense Response Response To External Biotic Stimulus Negative Regulation Of Myeloid Leukocyte Differentiation Regulation Of Acute Inflammatory Response B Cell Receptor Signaling Pathway B Cell Mediated Immunity Complement Activation Extracellular Space Antibacterial Humoral Response Host-mediated Perturbation Of Viral Process Negative Regulation Of Wound Healing Negative Regulation Of Viral Process Regulation Of Immune System Process Leukocyte Mediated Cytotoxicity Negative Regulation Of Myeloid Cell Differentiation Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Host-mediated Perturbation Of Symbiont Process Unfolded Protein Binding
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