MS4A2

Description		membrane spanning 4-domains A2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Fc-epsilon Receptor I Complex
	Molecular Function	Protein Binding IgE Binding
	Biological Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Omalizumab
Diseases		Asthma
GWAS		Alzheimer's disease ( 31473137)
Novel Interacting Genes		12 novel interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SNCA SYK TMEM86A
Interacting Genes		12 interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SNCA SYK TMEM86A
Entrez ID		2206
HPRD ID		00915
Ensembl ID		ENSG00000149534
Uniprot IDs		A0A0B4J2E9 Q01362
PDB IDs		8YVU 8YWA
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response Regulation Of Cell Activation Regulation Of Immune Response Immune Effector Process Regulation Of Immune System Process Regulation Of Innate Immune Response T Cell Costimulation Myeloid Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Activation Positive Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Neutrophil Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein-containing Complex Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin B Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Fc Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Response To Stress Regulation Of Transport Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Inflammatory Response Activation Of Innate Immune Response Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Protein Kinase Binding Positive Regulation Of Superoxide Anion Generation Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To External Biotic Stimulus
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