TPCN2

Description		two pore segment channel 2
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cytosol Endosome Membrane Membrane Late Endosome Membrane Melanosome Membrane Monoatomic Ion Channel Complex Endolysosome Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Calcium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Protein Kinase Binding Voltage-gated Channel Activity Identical Protein Binding NAADP-sensitive Calcium-release Channel Activity Phosphatidylinositol-3,5-bisphosphate Binding Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Lysosome Organization Regulation Of Autophagy Regulation Of Exocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Calcium-mediated Signaling Response To Vitamin D Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Developmental Pigmentation Release Of Sequestered Calcium Ion Into Cytosol Intracellular PH Reduction Transmembrane Transport Calcium Ion Transmembrane Transport Endocytosis Involved In Viral Entry Into Host Cell Endosome To Lysosome Transport Of Low-density Lipoprotein Particle
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 18488028) Blond vs. brown/black hair color ( 30531825) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cadmium levels ( 26025379) Cutaneous malignant melanoma ( 26237428) Estimated glomerular filtration rate ( 31152163 31015462) Hair color ( 29662168) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Nevus count or cutaneous melanoma ( 30429480) Systemic lupus erythematosus ( 33272962) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Novel Interacting Genes		1 novel interacting genes: ADRA1A
Interacting Genes		1 interacting genes: ADRA1A
Entrez ID		219931
HPRD ID		18218
Ensembl ID		ENSG00000162341
Uniprot IDs		Q59G56 Q8NHX9
PDB IDs		6NQ0 6NQ1 6NQ2 8OUO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Pilomotor Reflex Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Alpha1-adrenergic Receptor Activity Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Neuron-glial Cell Signaling Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Negative Regulation Of Heart Rate Adult Heart Development Positive Regulation Of Striated Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, GABAergic Reflex Adrenergic Receptor Signaling Pathway Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Regulation Of The Force Of Heart Contraction Positive Regulation Of Vasoconstriction Positive Regulation Of Heart Rate Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Heart Contraction Organ Growth Positive Regulation Of Muscle Contraction Smooth Muscle Contraction Regulation Of Action Potential Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Caveola Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Negative Regulation Of Autophagy Developmental Cell Growth Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Synaptic Transmission
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