F9

Description		coagulation factor IX
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Zymogen Activation
Pathways		Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Protein hydroxylation Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Venous thromboembolism ( 31676865)
Novel Interacting Genes		5 novel interacting genes: F2 F7 F8 GGCX LRP1
Interacting Genes		5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2158
HPRD ID		02385
Ensembl ID		ENSG00000101981
Uniprot IDs		P00740
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P 7AHV 8EPC 8EPH 8EPK 8OL9 9BVK 9BVR
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Positive Regulation Of Blood Coagulation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Coagulation Acute-phase Response Protein Maturation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Hemostasis Regulation Of Blood Coagulation Endopeptidase Activity Response To Astaxanthin Gamma-glutamyl Carboxylase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Calcium Ion Binding Serine-type Peptidase Activity Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Wound Healing Serine-type Endopeptidase Activity Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Negative Regulation Of Testosterone Biosynthetic Process Lipoprotein Particle Receptor Binding Regulation Of Response To Wounding Thrombospondin Receptor Activity Response To Genistein Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neutrophil-mediated Killing Of Gram-negative Bacterium Response To Thyroxine Response To Vitamin K Response To Hydroxyisoflavone Positive Regulation Of Lysosomal Protein Catabolic Process Response To L-phenylalanine Derivative Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Phenylpropanoid Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process
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