EZH1

Description		enhancer of zeste 1 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Nucleosome Binding Histone Methyltransferase Activity Histone Binding Histone H3K27 Methyltransferase Activity Molecular Condensate Scaffold Activity Histone H3K27 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs		Tazemetostat
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 31562340) Waist-hip index ( 34021172)
Novel Interacting Genes		3 novel interacting genes: E2F6 EED ZMYND11
Interacting Genes		3 interacting genes: E2F6 EED ZMYND11
Entrez ID		2145
HPRD ID		03397
Ensembl ID		ENSG00000108799
Uniprot IDs		A0A0A0MSY9 Q92800
PDB IDs		7KSO 7KSR 7KTP 7TD5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Pronucleus Sex Chromatin Histone H3K36me3 Reader Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Genomic Imprinting Regulation Of DNA-templated Transcription MLL1 Complex Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Epigenetic Programming Of Gene Expression Chromosome Nucleosome Binding Spinal Cord Development Negative Regulation Of JNK Cascade Chromatin Organization Regulation Of RNA Metabolic Process Oligodendrocyte Differentiation Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm
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