AK4

Description		adenylate kinase 4
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity CMP Kinase Activity DCMP Kinase Activity Nucleoside Triphosphate Adenylate Kinase Activity DAMP Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Regulation Of Oxidative Phosphorylation Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleoside Diphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Nucleoside Monophosphate Phosphorylation Cellular Response To Hypoxia
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841)
Novel Interacting Genes		4 novel interacting genes: APP CEP19 EPHA8 KEAP1
Interacting Genes		4 interacting genes: APP CEP19 EPHA8 KEAP1
Entrez ID		205
HPRD ID		00048
Ensembl ID		ENSG00000162433
Uniprot IDs		F8VS11 P27144
PDB IDs		2AR7 2BBW 3NDP
Enriched GO Terms of Interacting Partners?		Neuron Remodeling Neuron Maturation Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Developmental Maturation Early Endosome Membrane Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Vesicle Targeting, To, From Or Within Golgi Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cell Projection Organization Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Cell Projection Axon Choice Point Recognition GPI-linked Ephrin Receptor Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparan Sulfate Binding Signaling Receptor Activator Activity Substrate-dependent Cell Migration
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