EN2

Description		engrailed homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Dopaminergic Neuron Differentiation Embryonic Brain Development
Pathways
Drugs		N-cyclohexyltaurine
Diseases
GWAS		Cytomegalovirus pp28 antibody levels ( 33204752) HDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483)
Novel Interacting Genes		2 novel interacting genes: EIF4E FOXA2
Interacting Genes		2 interacting genes: EIF4E FOXA2
Entrez ID		2020
HPRD ID		08836
Ensembl ID		ENSG00000164778
Uniprot IDs		P19622
PDB IDs
Enriched GO Terms of Interacting Partners?		Eukaryotic Initiation Factor 4G Binding Neuron Differentiation MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Negative Regulation Of Cell Differentiation Eukaryotic Translation Initiation Factor 4F Complex Primitive Streak Formation Positive Regulation Of Gastrulation Regulation Of Gastrulation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Endocrine Pancreas Development Positive Regulation Of Embryonic Development Response To Interleukin-6 Negative Regulation Of Developmental Process Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Dopaminergic Neuron Differentiation Fear Response Response To Dexamethasone Negative Regulation Of Epithelial To Mesenchymal Transition Translation Initiation Factor Activity RNA Export From Nucleus Cell Cycle G1/S Phase Transition Cellular Response To Steroid Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cytoplasmic Ribonucleoprotein Granule Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus MRNA Export From Nucleus Multicellular Organismal Response To Stress Translational Initiation Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Adult Locomotory Behavior Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Embryonic Development Cell Fate Specification RISC Complex Cytoplasmic Stress Granule
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