EN1

Description		engrailed homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellum Development Central Nervous System Neuron Differentiation Neuron Differentiation Embryonic Limb Morphogenesis Midbrain Development Hindbrain Development Midbrain-hindbrain Boundary Development Embryonic Forelimb Morphogenesis Social Behavior Multicellular Organism Growth Response To Cocaine Drinking Behavior Pigmentation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Limb Development Motor Learning Dopaminergic Neuron Differentiation Embryonic Brain Development
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Blond vs. brown/black hair color ( 30531825) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Bone ultrasound measurement (velocity of sound) ( 28472463) California verbal learning test score ( 31596458) Femoral neck bone mineral density ( 26367794 29499414) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 26367794) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Mosquito bite size ( 28199695) Multiple sclerosis ( 19010793)
Novel Interacting Genes		3 novel interacting genes: JUN PAX6 TLE1
Interacting Genes		3 interacting genes: JUN PAX6 TLE1
Entrez ID		2019
HPRD ID		08835
Ensembl ID		ENSG00000163064
Uniprot IDs		Q05925
PDB IDs
Enriched GO Terms of Interacting Partners?		R-SMAD Binding Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Regulator Complex Response To Anisomycin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Anisomycin Negative Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Gland Development Anatomical Structure Morphogenesis Leading Edge Cell Differentiation Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Response To Wounding Regulation Of Asymmetric Cell Division Habenula Development Oligodendrocyte Cell Fate Specification Pallium Development Release From Viral Latency Ubiquitin Protein Ligase Binding Transcription Factor AP-1 Complex Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Formation Of Anatomical Boundary Glial Cell Fate Specification Regulation Of Epithelial Cell Proliferation Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Cell Surface Receptor Signaling Pathway Epithelial Cell Differentiation Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Host-mediated Suppression Of Viral Transcription Negative Regulation Of Macromolecule Biosynthetic Process Neuron Projection Development Chromatin Binding Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific CAMP Response Element Binding
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