PDE12

Description		phosphodiesterase 12
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Catalytic Activity Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Mitochondrial MRNA Catabolic Process MRNA Processing Cellular Response To Interferon-alpha Regulation Of Mitochondrial MRNA Stability Positive Regulation Of Viral Genome Replication Defense Response To Virus Cellular Response To Type II Interferon Cellular Response To DsRNA Nucleic Acid Metabolic Process Antiviral Innate Immune Response
Pathways		OAS antiviral response
Drugs
Diseases
GWAS
Novel Interacting Genes		3 novel interacting genes: DNAH12 FBXO7 UBC
Interacting Genes		3 interacting genes: DNAH12 FBXO7 UBC
Entrez ID		201626
HPRD ID		11842
Ensembl ID		ENSG00000174840
Uniprot IDs		F6T1Q0 Q6L8Q7
PDB IDs		4Z0V 4Z2B 4ZKF
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Tag Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Minus-end-directed Microtubule Motor Activity Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Post-translational Protein Modification
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