UNC13D

Description		unc-13 homolog D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Recycling Endosome Exocytic Vesicle
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Granuloma Formation Germinal Center Formation Exocytosis Phagocytosis Regulation Of Mast Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Secretion Defense Response To Virus Establishment Of Localization In Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway
Pathways		Neutrophil degranulation
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059 34103634) Eosinophil count ( 27863252) Major depressive disorder ( 27777418) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White matter hyperintensity burden ( 25663218)
Novel Interacting Genes		3 novel interacting genes: LMNA RAB27A RAB27B
Interacting Genes		3 interacting genes: LMNA RAB27A RAB27B
Entrez ID		201294
HPRD ID		10598
Ensembl ID		ENSG00000092929
Uniprot IDs		Q70J99
PDB IDs
Enriched GO Terms of Interacting Partners?		Myosin V Binding Multivesicular Body Membrane Exocytic Vesicle Multivesicular Body Sorting Pathway GDP Binding G Protein Activity Positive Regulation Of Exocytosis Melanosome Secretory Granule Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Transport Late Endosome DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Regulation Of Exocytosis Establishment Of Protein Localization Exocytosis Protein Domain Specific Binding Complement-dependent Cytotoxicity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Establishment Of Organelle Localization Establishment Of Localization In Cell Exosomal Secretion Lamin Filament Nuclear Pore Localization Positive Regulation Of Secretion By Cell GTPase Activity Positive Regulation Of Secretion Weibel-Palade Body Platelet Dense Granule Membrane Intracellular Protein Localization Natural Killer Cell Degranulation Negative Regulation Of Mesenchymal Cell Proliferation Apical Plasma Membrane GTP Binding Secretion By Cell Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Organelle Localization Nuclear Lamina Protein Transport Along Microtubule Protein Localization To Nuclear Envelope Secretion Intracellular Protein Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Zymogen Granule Membrane
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