ARHGAP27

Description		Rho GTPase activating protein 27
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity SH3 Domain Binding Actin Filament Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Refractive error ( 32231278) Systemic lupus erythematosus ( 29848360) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		4 novel interacting genes: CDC42 RAC1 RETREG3 SH3KBP1
Interacting Genes		4 interacting genes: CDC42 RAC1 RETREG3 SH3KBP1
Entrez ID		201176
HPRD ID		12477
Ensembl ID		ENSG00000159314
Uniprot IDs		A0A8I5KVA8 E9PIR1 E9PNT2 E9PNX6 Q6ZUM4 Q8N2Y9
PDB IDs		3PP2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Phagocytosis, Engulfment Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Membrane Invagination Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Focal Adhesion Endocytosis Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Supramolecular Fiber Organization G Protein Activity Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Import Into Cell Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion Organelle Organization Regulation Of Postsynapse Organization GBD Domain Binding Storage Vacuole Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Cell Shape Cerebral Cortex GABAergic Interneuron Development Establishment Or Maintenance Of Cell Polarity Cell Migration Positive Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Cytoskeleton Organization Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Cytoskeleton Organization Cell-cell Junction
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