FBXO45

Description		F-box protein 45
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane SCF Ubiquitin Ligase Complex Presynaptic Membrane Cell Projection Organelle Synapse Postsynaptic Membrane Presynapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Neuron Migration Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nervous System Development Protein Ubiquitination Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Corticospinal Tract Morphogenesis Anterior Commissure Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innervation Synapse Assembly Involved In Innervation Axon Development Protein K48-linked Ubiquitination Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851 34103634) Multiple sclerosis ( 31604244) Vitiligo ( 27723757)
Novel Interacting Genes		8 novel interacting genes: FBXW7 PRNP RBX1 SNAI1 SNAI2 TP73 TWIST1 ZEB2
Interacting Genes		8 interacting genes: FBXW7 PRNP RBX1 SNAI1 SNAI2 TP73 TWIST1 ZEB2
Entrez ID		200933
HPRD ID		19508
Ensembl ID		ENSG00000174013
Uniprot IDs		P0C2W1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Ameboidal-type Cell Migration Epithelial Cell Migration Aortic Valve Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Cellular Response To Stress Heart Valve Morphogenesis Regulation Of Intracellular Signal Transduction E-box Binding Regulation Of Cell Communication Regulation Of RNA Metabolic Process Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Cartilage Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Vitamin Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Lipid Metabolic Process Mesenchymal Cell Differentiation Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Osteoblast Differentiation
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