DHFR2

Description		dihydrofolate reductase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity Protein Binding Oxidoreductase Activity Folate Reductase Activity NADP Binding
	Biological Process	One-carbon Metabolic Process Thymidine Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process
Pathways		Metabolism of folate and pterines
Drugs		5-Chloryl-2,4,6-quinazolinetriamine 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine 5-Phenylsulfanyl-2,4-Quinazolinediamine 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE Epigallocatechin gallate
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: ARL13B TINF2
Interacting Genes		2 interacting genes: ARL13B TINF2
Entrez ID		200895
HPRD ID		11246
Ensembl ID		ENSG00000178700
Uniprot IDs		B3KV46 Q86XF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome, Telomeric Region Perinucleolar Chromocenter Protein Localization To Organelle Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Telomere Assembly Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Formation Of Radial Glial Scaffolds Receptor Localization To Non-motile Cilium Left/right Axis Specification Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Non-motile Cilium Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Telomere Maintenance Via Telomere Lengthening Non-motile Cilium Assembly Ciliary Membrane Heart Looping Protein Localization To Cilium Dorsal/ventral Pattern Formation Embryonic Heart Tube Morphogenesis Positive Regulation Of Telomere Maintenance Intracellular Protein Localization Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Smoothened Signaling Pathway Determination Of Bilateral Symmetry Intercellular Bridge Determination Of Left/right Symmetry Axis Specification Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Epithelial Tube Morphogenesis Axoneme Telomere Organization Nuclear Matrix Negative Regulation Of DNA Metabolic Process Negative Regulation Of Epithelial Cell Proliferation
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