AGO3

Description		argonaute RISC catalytic component 3
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA
	Biological Process	MRNA Catabolic Process Regulation Of Translation Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization RISC Complex Assembly Regulation Of Stem Cell Proliferation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS
Novel Interacting Genes		6 novel interacting genes: ATP4B ATP6V0D2 BDNF CFTR CXCR4 SLC22A2
Interacting Genes		6 interacting genes: ATP4B ATP6V0D2 BDNF CFTR CXCR4 SLC22A2
Entrez ID		192669
HPRD ID		09558
Ensembl ID		ENSG00000126070
Uniprot IDs		B4E1P5 Q9H9G7
PDB IDs		5VM9 8VAJ
Enriched GO Terms of Interacting Partners?		Regulation Of PH Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Transmembrane Transport Export Across Plasma Membrane Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Early Endosome Regulation Of Cellular PH Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Intracellular PH C-X-C Motif Chemokine 12 Receptor Activity Monoatomic Ion Homeostasis Cellular Homeostasis Import Across Plasma Membrane Inorganic Ion Transmembrane Transport P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Intracellular Chemical Homeostasis Proton Transmembrane Transport Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Plasma Membrane Proton-transporting V-type ATPase Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Nerve Growth Factor Receptor Binding Endosome Transepithelial Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity
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