S1PR3

Description		sphingosine-1-phosphate receptor 3
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Presynapse
	Molecular Function	G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		G alpha (i) signalling events Lysosphingolipid and LPA receptors Extra-nuclear estrogen signaling
Drugs		Fingolimod
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte percentage of white cells ( 27863252 32888494) Response to statins (LDL cholesterol change) ( 22331829) Spleen volume ( 34128465) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Novel Interacting Genes		6 novel interacting genes: COMT GNA13 GNAI1 GNAQ GYPB HTR1A
Interacting Genes		6 interacting genes: COMT GNA13 GNAI1 GNAQ GYPB HTR1A
Entrez ID		1903
HPRD ID		03572
Ensembl ID		ENSG00000213694
Uniprot IDs		Q99500
PDB IDs		7C4S 7EW2 7EW3 7EW4
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Response To Prostaglandin E Behavioral Fear Response Exploration Behavior Behavioral Defense Response Response To Alcohol G Protein-coupled Receptor Signaling Pathway Fear Response GTPase Activity GTP Binding Multicellular Organismal Response To Stress Norepinephrine Secretion Catechol O-methyltransferase Activity Phenol-containing Compound Metabolic Process Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Neuropeptide Signaling Pathway Cellular Response To Phosphate Starvation D5 Dopamine Receptor Binding Detection Of Abiotic Stimulus Response To Hormone D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Receptor-receptor Interaction Regulation Of Blood Pressure Cerebellar Cortex Morphogenesis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Serotonin Secretion Response To Lipid Dopamine Secretion Positive Regulation Of Protein Localization To Cell Cortex
Tagcloud ?