DUSP9

Description		dual specificity phosphatase 9
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	MAPK Cascade Protein Dephosphorylation Signal Transduction JNK Cascade Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Body mass index ( 28892062) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hemoglobin A1c levels ( 29403010) Type 2 diabetes ( 20581827 22961080 23945395 30718926)
Novel Interacting Genes		7 novel interacting genes: AATK CDK4 GSK3B MAPK1 MAPK10 MAPK14 MAPK3
Interacting Genes		7 interacting genes: AATK CDK4 GSK3B MAPK1 MAPK10 MAPK14 MAPK3
Entrez ID		1852
HPRD ID		02136
Ensembl ID		ENSG00000130829
Uniprot IDs		B2RAL9 Q6P9C2 Q99956
PDB IDs		2HXP 3LJ8
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity MAP Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cellular Response To Cytokine Stimulus Lipopolysaccharide-mediated Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Cytokine Response To Peptide Regulation Of Golgi Inheritance MAPK Cascade Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Response To Lipopolysaccharide Insulin Receptor Signaling Pathway Response To Lipid Response To Molecule Of Bacterial Origin Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Protein Phosphorylation Intracellular Signaling Cassette Cellular Response To Tumor Necrosis Factor Bergmann Glial Cell Differentiation Phosphorylation Regulation Of Ossification Response To Tumor Necrosis Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway MAP Kinase Kinase Activity Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Regulation Of Cellular Localization Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity Face Development Positive Regulation Of Cell Migration ERBB2 Signaling Pathway
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