DUSP5

Description		dual specificity phosphatase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	MAPK Cascade Endoderm Formation Protein Dephosphorylation Signal Transduction Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23850713) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Non-albumin protein levels ( 29403010) Total body bone mineral density ( 29304378)
Novel Interacting Genes		5 novel interacting genes: AATK FBN2 MAPK1 MAPK3 MTDH
Interacting Genes		5 interacting genes: AATK FBN2 MAPK1 MAPK3 MTDH
Entrez ID		1847
HPRD ID		04349
Ensembl ID		ENSG00000138166
Uniprot IDs		Q16690
PDB IDs		2G6Z
Enriched GO Terms of Interacting Partners?		Interleukin-34-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Ossification Regulation Of Golgi Organization MAP Kinase Activity Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Face Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration Neural Crest Cell Development Lung Morphogenesis Regulation Of Macrophage Chemotaxis Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Stem Cell Development Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Exogenous DsRNA Regulation Of Neuroinflammatory Response Regulation Of Macrophage Migration Response To DsRNA Phosphotyrosine Residue Binding Thymus Development Protein Serine Kinase Activity Regulation Of Granulocyte Chemotaxis Phosphatase Binding Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Protein Serine/threonine Kinase Activity Anchoring Junction Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development
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