DRD4

Description		dopamine receptor D4
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GO Annotations	Cellular Component	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Dopamine receptors G alpha (i) signalling events
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS
Novel Interacting Genes		13 novel interacting genes: ADCY2 ADRB2 CARS1 CLIC6 ETNK1 GABRA1 GNAI1 GRB2 KCNJ9 KIF2C KLHL12 MKI67 NCK1
Interacting Genes		13 interacting genes: ADCY2 ADRB2 CARS1 CLIC6 ETNK1 GABRA1 GNAI1 GRB2 KCNJ9 KIF2C KLHL12 MKI67 NCK1
Entrez ID		1815
HPRD ID		00541
Ensembl ID		ENSG00000069696
Uniprot IDs		P21917
PDB IDs		5WIU 5WIV
Enriched GO Terms of Interacting Partners?		D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity
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