DPP6

Description		dipeptidyl peptidase like 6
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane
	Molecular Function	Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Potassium Channel Regulator Activity
	Biological Process	Proteolysis Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways
Drugs
Diseases		Familial idiopathic ventricular fibrillation
GWAS		Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) Amyotrophic lateral sclerosis ( 18084291 18987618 18057069) Bitter alcoholic beverage consumption ( 31046077) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Carotid intima media thickness x smoking interaction ( 32117412) Colorectal cancer (diet interaction) ( 24743840) Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect) ( 27490719) Gut microbiota relative abundance (Coprococcus) ( 33208821) Height ( 28552196) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lean body mass ( 28552196) Pancreatic cancer ( 20686608) Pelvic organ prolapse ( 26545240) Post bronchodilator FEV1 in COPD ( 26634245) Post-traumatic stress disorder ( 24677629) Problematic alcohol use ( 32451486) QT interval ( 23534349) Regular attendance at a pub or social club ( 29970889) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tardive dyskinesia ( 21826085) Thalamus volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Novel Interacting Genes		1 novel interacting genes: PRNP
Interacting Genes		1 interacting genes: PRNP
Entrez ID		1804
HPRD ID		00525
Ensembl ID		ENSG00000130226
Uniprot IDs		A0A994J521 A0A994J7K0 A7E2E4 B7Z299 E9PDL2 E9PF59 P42658 Q8IYG9
PDB IDs		1XFD 7E87 7E89 7E8B 7E8E 7E8G 7E8H 7UKG
Enriched GO Terms of Interacting Partners?		ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid-beta Formation Molecular Function Activator Activity Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Interleukin-2 Production Cellular Response To Copper Ion Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Targeting To Membrane Regulation Of Activated T Cell Proliferation Regulation Of Long-term Synaptic Potentiation Long-term Memory Neuron Projection Organization Regulation Of Amyloid-beta Formation Terminal Bouton Negative Regulation Of Type II Interferon Production Dendritic Spine Organization Postsynapse Organization Regulation Of Calcineurin-mediated Signaling Response To Copper Ion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Calcium Ion Import Copper Ion Binding Molecular Condensate Scaffold Activity
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