DPEP1

Description		dipeptidase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Microvillus Membrane Cell Projection Apical Part Of Cell Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Beta-lactamase Activity Hydrolase Activity Dipeptidase Activity GPI Anchor Binding Metal Ion Binding Metallodipeptidase Activity Modified Amino Acid Binding
	Biological Process	Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Catabolic Process Inflammatory Response Antibiotic Metabolic Process Negative Regulation Of Cell Migration Neutrophil Chemotaxis Homocysteine Metabolic Process Cellular Response To Calcium Ion Cellular Response To Nitric Oxide Lactam Catabolic Process Leukotriene D4 Catabolic Process
Pathways		Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production
Drugs		Cilastatin
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Diastolic blood pressure ( 27618447 27618448 27841878) Estimated glomerular filtration rate ( 31451708 30604766 29124443) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Homocysteine levels ( 23824729) Hypertension ( 27618447) Hyperuricemia ( 29124443) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Red vs. brown/black hair color ( 30531825) Serum metabolite levels ( 33031748) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27618447 27841878) Urinary albumin-to-creatinine ratio ( 31511532) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		2 novel interacting genes: APPBP2 KIFBP
Interacting Genes		2 interacting genes: APPBP2 KIFBP
Entrez ID		1800
HPRD ID		01563
Ensembl ID		ENSG00000015413
Uniprot IDs		A0A140VJI3 P16444
PDB IDs		1ITQ 1ITU
Enriched GO Terms of Interacting Partners?		Microtubule Associated Complex Intracellular Transport Cul2-RING Ubiquitin Ligase Complex Central Nervous System Projection Neuron Axonogenesis Establishment Of Mitochondrion Localization Central Nervous System Neuron Axonogenesis Neuron Projection Organization Neuron Projection Maintenance Mitochondrion Transport Along Microtubule Kinesin Binding Protein Sequestering Activity Cellular Localization Cytoskeleton Microtubule Motor Activity Establishment Of Localization In Cell Mitochondrion Localization
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