DXO

Description		decapping exoribonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity MRNA 5'-diphosphatase Activity Metal Ion Binding RNA NAD+-cap (NAD+-forming) Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Metabolic Process NAD-cap Decapping
Pathways		Nuclear RNA decay
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Novel Interacting Genes		9 novel interacting genes: DAXX EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Interacting Genes		9 interacting genes: DAXX EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2
Entrez ID		1797
HPRD ID		16186
Ensembl ID		ENSG00000204348
Uniprot IDs		A0A024RCW8 A0A1U9X7N5 F8WC68 O77932
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Nuclear RNA Surveillance Negative Regulation Of Gene Expression RNA Surveillance Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear Exosome (RNase Complex) RRNA Catabolic Process RRNA Metabolic Process Exosome (RNase Complex) Negative Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Exonuclease Activity Nucleolus SnRNA Metabolic Process RRNA Processing Macromolecule Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Regulation Of Gene Expression RNA 3'-end Processing Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process RRNA 3'-end Processing 5'-3' Exonuclease Activity TRNA Decay RNA Metabolic Process Regulation Of Telomere Maintenance Nuclease Activity RNA Binding Regulation Of Macromolecule Metabolic Process Sno(s)RNA Metabolic Process
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