DOCK3

Description		dedicator of cytokinesis 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding
	Biological Process	Small GTPase-mediated Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle NTRK2 activates RAC1 NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Asthma ( 32296059) Bacteremia ( 27236921) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Colorectal cancer ( 29228715) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 31152163) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 24980573) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		11 novel interacting genes: CALM1 CRK HOXA1 KHDRBS1 NR3C1 PLEKHF2 PSEN1 PSEN2 RAC1 RSPH1 SRPK2
Interacting Genes		11 interacting genes: CALM1 CRK HOXA1 KHDRBS1 NR3C1 PLEKHF2 PSEN1 PSEN2 RAC1 RSPH1 SRPK2
Entrez ID		1795
HPRD ID		10341
Ensembl ID		ENSG00000088538
Uniprot IDs		Q8IZD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrion-endoplasmic Reticulum Membrane Tethering Protein-containing Complex Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Gamma-secretase Complex Notch Receptor Processing Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid-beta Formation Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Amyloid Precursor Protein Catabolic Process Neuron Migration Presynaptic Membrane Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Cochlea Morphogenesis Neuron Development Cerebral Cortex Cell Migration Membrane Protein Proteolysis Regulation Of Synaptic Plasticity Regulation Of Cellular Localization Early Endosome Membrane Positive Regulation Of Dendritic Spine Development SH2 Domain Binding Protein Tyrosine Kinase Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Dendrite Development Central Nervous System Neuron Development Telencephalon Cell Migration Forebrain Cell Migration G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Neuron Apoptotic Process Regulation Of Dendritic Spine Development Cell Cycle G2/M Phase Transition Cell Surface Receptor Signaling Pathway Centrosome Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Transforming Growth Factor Beta Stimulus Nuclear Glucocorticoid Receptor Activity Semicircular Canal Formation Negative Regulation Of Core Promoter Binding Positive Regulation Of Nucleocytoplasmic Transport Grb2-Sos Complex Synaptic Membrane Tube Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Signal Transduction
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