AGL

Description		amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Response To Hormone Response To Glucocorticoid
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Novel Interacting Genes		3 novel interacting genes: APPL1 NHLRC1 PRKAB1
Interacting Genes		3 interacting genes: APPL1 NHLRC1 PRKAB1
Entrez ID		178
HPRD ID		01984
Ensembl ID		ENSG00000162688
Uniprot IDs		A0A0S2A4E4 P35573
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Membrane Macropinosome Nucleotide-activated Protein Kinase Complex Nail Development Response To Hepatocyte Growth Factor Regulation Of Melanin Biosynthetic Process Positive Regulation Of Pinocytosis Early Phagosome Regulation Of Cellular Localization Positive Regulation Of Melanin Biosynthetic Process Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Adiponectin-activated Signaling Pathway Glycogen Biosynthetic Process Intracellular Vesicle Negative Regulation Of Phagocytosis Polysaccharide Biosynthetic Process Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of D-glucose Import Vesicle Membrane
Tagcloud ?