DNASE2

Description		deoxyribonuclease 2, lysosomal
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Extracellular Exosome
	Molecular Function	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Deoxyribonuclease II Activity Protein Binding Hydrolase Activity
	Biological Process	DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Enucleate Erythrocyte Differentiation Regulation Of Immune Response
Pathways		Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Immature fraction of reticulocytes ( 27863252) Mean corpuscular volume ( 29403010) Red cell distribution width ( 28957414)
Novel Interacting Genes		2 novel interacting genes: DNMT1 XRN1
Interacting Genes		2 interacting genes: DNMT1 XRN1
Entrez ID		1777
HPRD ID		00531
Ensembl ID		ENSG00000105612
Uniprot IDs		O00115
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Puromycin Cellular Response To Cycloheximide DNA-methyltransferase Activity Germ Cell Nucleus DNA (cytosine-5-)-methyltransferase Activity Regulation Of Phenotypic Switching Cellular Response To Bisphenol A Response To Cycloheximide 5'-3' RNA Exonuclease Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Female Germ Cell Nucleus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Histone MRNA Catabolic Process RRNA Catabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Differentiation Cellular Response To Oxygen-containing Compound Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Histone MRNA Metabolic Process Replication Fork LncRNA Binding Methyl-CpG Binding Pericentric Heterochromatin Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Epigenetic Programming Of Gene Expression Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Nuclear RNA Surveillance Negative Regulation Of Telomere Maintenance RNA Surveillance Response To Testosterone Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Smooth Muscle Cell Differentiation Exonuclease Activity RNA Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Heterochromatin
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