DMRT1

Description		doublesex and mab-3 related transcription factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Male Germ Cell Proliferation Regulation Of Transcription By RNA Polymerase II Germ Cell Development Spermatogenesis Sex Differentiation Germ Cell Migration Male Sex Determination Intracellular Signal Transduction Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Male Sex Differentiation Oocyte Development Sertoli Cell Differentiation Sertoli Cell Development Positive Regulation Of Meiosis I Regulation Of Nodal Signaling Pathway Positive Regulation Of Male Gonad Development
Pathways		Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Dupuytren's disease ( 28886342) Major depressive disorder ( 23377640) Medial orbital frontal cortex volume ( 31530798) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Testicular cancer ( 21551455) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666239 23666240) Uterine fibroids ( 30194396)
Interacting Genes		1 interacting genes: TRIM29
Entrez ID		1761
HPRD ID		03885
Ensembl ID		ENSG00000137090
Uniprot IDs		Q9Y5R6
PDB IDs		4YJ0
Enriched GO Terms of Interacting Partners?
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