DHCR24

Description		24-dehydrocholesterol reductase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Delta24(24-1) Sterol Reductase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Enzyme Binding Peptide Antigen Binding Delta24-sterol Reductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Ras Protein Signal Transduction Intracellular Protein Localization Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Cell Population Proliferation Response To Hormone Tissue Development Sterol Metabolic Process Sterol Biosynthetic Process Male Genitalia Development Plasminogen Activation Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Amyloid Precursor Protein Catabolic Process Skin Development Membrane Organization
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases		Desmosterolosis
GWAS		Visceral fat, circulating phospholipid PC(16:0/2:0) and white matter microstructure (shared variance) ( 31900429)
Novel Interacting Genes		2 novel interacting genes: CCR4 TP53
Interacting Genes		2 interacting genes: CCR4 TP53
Entrez ID		1718
HPRD ID		05916
Ensembl ID		ENSG00000116133
Uniprot IDs		Q15392
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Interneuron Migration Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Regulation Of Thymocyte Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of ATP-dependent Activity ER Overload Response Mitotic G1 DNA Damage Checkpoint Signaling MDM2/MDM4 Family Protein Binding TFIID-class Transcription Factor Complex Binding Replicative Senescence Positive Regulation Of Programmed Necrotic Cell Death Type II Interferon-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Antibiotic Negative Regulation Of Mitophagy Necroptotic Process General Transcription Initiation Factor Binding Regulation Of Regulatory NcRNA Processing
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