DGUOK

Description		deoxyguanosine kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Nucleotide Binding Deoxyadenosine Kinase Activity Deoxyguanosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Deoxynucleoside Kinase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Guanosine Metabolic Process Negative Regulation Of Neuron Projection Development Mitochondrial ATP Synthesis Coupled Electron Transport DGTP Metabolic Process Purine Deoxyribonucleoside Metabolic Process DAMP Salvage Carbohydrate Derivative Metabolic Process
Pathways		Purine salvage
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Dialysis-related mortality ( 21546767) Systemic lupus erythematosus ( 23273568)
Novel Interacting Genes		4 novel interacting genes: APP FAM9B LIG4 PXN
Interacting Genes		4 interacting genes: APP FAM9B LIG4 PXN
Entrez ID		1716
HPRD ID		03273
Ensembl ID		ENSG00000114956
Uniprot IDs		E5KSL5 Q16854
PDB IDs		2OCP
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Regulation Of Response To Calcium Ion Cell Activation Involved In Immune Response Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Low-density Lipoprotein Particle Mediated Signaling Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Positive Regulation Of Cellular Component Organization Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Regulation Of Neuron Apoptotic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Axon Choice Point Recognition DNA-dependent Protein Kinase-DNA Ligase 4 Complex Heparan Sulfate Binding Signaling Receptor Activator Activity
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