SYNPO2

Description		synaptopodin 2
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Z Disc Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Filamin Binding Muscle Alpha-actinin Binding Alpha-actinin Binding 14-3-3 Protein Binding
	Biological Process	Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aortic vascular smooth muscle cell calcification in response to osteogenic stimuli ( 33040646) Diastolic blood pressure ( 30224653) Epithelial ovarian cancer ( 25581431) Estimated glomerular filtration rate after 5 years in renal transplantation (donor effect) ( 30920136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) IgE levels in asthmatics ( 23967269)
Novel Interacting Genes		7 novel interacting genes: ACTN2 CDK6 FLNA FLNC NEDD4 YWHAG YWHAZ
Interacting Genes		7 interacting genes: ACTN2 CDK6 FLNA FLNC NEDD4 YWHAG YWHAZ
Entrez ID		171024
HPRD ID		15456
Ensembl ID		ENSG00000172403
Uniprot IDs		B4DLE4 B4E258 Q9UMS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Focal Adhesion Protein Sequestering Activity Protein Domain Specific Binding Phosphoserine Residue Binding Regulation Of Potassium Ion Transport Positive Regulation Of Intracellular Transport Z Disc Glutamatergic Synapse Actin Filament Binding Negative Regulation Of Potassium Ion Transport Protein Targeting Positive Regulation Of Potassium Ion Transport Regulation Of Intracellular Transport Regulation Of Monoatomic Cation Transmembrane Transport Sarcomere Organization Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Glucose Starvation Cytoskeletal Protein Binding Intracellular Protein Localization Actin Binding Cell Development Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Metal Ion Transport Cytosol Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Stability Positive Regulation Of Nucleocytoplasmic Transport Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling TORC1 Signaling Actin Filament Uncapping Cyclin D2-CDK6 Complex Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Formation Of Structure Involved In A Symbiotic Process Extracellular Exosome Actin Filament-based Process Regulation Of Monoatomic Ion Transport TOR Signaling Actin Filament Regulation Of Membrane Potential Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of TOR Signaling Protein Localization To Vacuole Muscle Cell Development Negative Regulation Of Biosynthetic Process Regulation Of TORC1 Signaling Titin Z Domain Binding Negative Regulation Of Monoatomic Ion Transport
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