ADAMTS18

Description		ADAM metallopeptidase with thrombospondin type 1 motif 18
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Eye Development Proteolysis Extracellular Matrix Organization Negative Regulation Of Platelet Aggregation
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Bone mineral density ( 19249006) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29235454 29617998 30054594 31959993) Type 2 diabetes (age of onset) ( 28060188) Upper eyelid sagging severity ( 29654602) White matter integrity ( 22425255)
Interacting Genes		1 interacting genes: SRPK2
Entrez ID		170692
HPRD ID		06333
Ensembl ID		ENSG00000140873
Uniprot IDs		Q2VYF7 Q6ZN25 Q8TE60
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Speck Organization R-loop Processing Peptidyl-serine Phosphorylation 14-3-3 Protein Binding Nuclear Body Organization Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Neuron Apoptotic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Positive Regulation Of Viral Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleus Organization Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome
Tagcloud ?