DEFA5

Description		defensin alpha 5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Transport Vesicle Secretory Granule Midbody Cytoplasmic Vesicle Secretory Granule Lumen
	Molecular Function	Protein Binding Protein Homodimerization Activity Pore-forming Activity
	Biological Process	Immune System Process Defense Response Antibacterial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Protein Homotetramerization Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Membrane Permeability
Pathways		Defensins Alpha-defensins Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 30072576) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Mercury levels ( 26025379)
Novel Interacting Genes		5 novel interacting genes: ACE2 BMI1 DTX1 MEOX2 PRSS1
Interacting Genes		5 interacting genes: ACE2 BMI1 DTX1 MEOX2 PRSS1
Entrez ID		1670
HPRD ID		02720
Ensembl ID		ENSG00000164816
Uniprot IDs		Q01523
PDB IDs		1ZMP 2LXZ 2MIT 3I5W 4E82 4E83 4E86 4RBW 4RBX 5CUI 5CUJ 5CUM
Enriched GO Terms of Interacting Partners?		Segment Specification Regulation Of Adaxial/abaxial Pattern Formation Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Entry Receptor-mediated Virion Attachment To Host Cell Viral Translation Viral Life Cycle Somite Specification Tryptophan Transport Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Gap Junction Assembly Receptor-mediated Virion Attachment To Host Cell Somatic Stem Cell Division Ubiquitin-protein Transferase Activator Activity Regulation Of Immature T Cell Proliferation In Thymus Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Positive Regulation Of Ubiquitin-protein Transferase Activity Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Regulation Of DNA-templated Transcription Regulation Of Leukocyte Cell-cell Adhesion Nuclear Body Regulation Of RNA Biosynthetic Process Somite Development Regulation Of T Cell Activation
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