PARP15

Description		poly(ADP-ribose) polymerase family member 15
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD+ Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Protein Poly-ADP-ribosylation
Pathways
Drugs		N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
Diseases
GWAS		Major depressive disorder ( 22472876) Periodontitis (CDC/AAP) ( 24024966)
Novel Interacting Genes		2 novel interacting genes: APP NRM
Interacting Genes		2 interacting genes: APP NRM
Entrez ID		165631
HPRD ID		08811
Ensembl ID		ENSG00000173200
Uniprot IDs		B7ZL48 C9J7L3 Q460N3
PDB IDs		3BLJ 3GEY 3V2B 4F0E 6EK3 6RY4 7F41 7F42 7F43 7OQQ 7OSP 7OSS 7OSX 7OTF 7OTH 7OUW 7OUX 7PW3 7PWA 7PWC 7PWK 7PWL 7PWM 7PWP 7PWQ 7PWR 7PWS 7PWU 7PWW 7PX6 7PX7 7R3O 7R4A 7R5D 7Z1V 7Z1W 7Z1Y 7Z2O 7Z2Q 7Z41
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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