DDX5

Description		DEAD-box helicase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding Calmodulin Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Nuclear Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing MRNA Transcription BMP Signaling Pathway Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Primary MiRNA Processing Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway MiRNA Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of MiRNA Transcription Regulation Of Skeletal Muscle Cell Differentiation
Pathways		SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome
Drugs		Artenimol
Diseases		Prostate cancer
GWAS		Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Novel Interacting Genes		40 novel interacting genes: AKAP8 CALM1 CASP8 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11
Interacting Genes		40 interacting genes: AKAP8 CALM1 CASP8 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11
Entrez ID		1655
HPRD ID		01615
Ensembl ID		ENSG00000108654
Uniprot IDs		J3KTA4 P17844
PDB IDs		3FE2 4A4D
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of RNA Splicing Protein-containing Complex Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Estrogen Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Presynaptic Cytosol Signal Transduction MRNA Processing Postsynaptic Cytosol Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Response To Lipid Transcription Regulator Complex Chromatin Remodeling Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Processing Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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