TMPRSS6

Description		transmembrane serine protease 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Intracellular Iron Ion Homeostasis Extracellular Matrix Disassembly BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Collagen Catabolic Process Membrane Protein Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Self Proteolysis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Clinical laboratory measurements ( 27897004) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycated hemoglobin levels ( 34059833 31213470 28898252 20858683) Hematocrit ( 32888494 19862010 29403010 28453575 28017375 27863252) Hematological and biochemical traits ( 31902109 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 19862010 28453575 19820698 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375 33491795) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) Hepcidin/transferrin saturation ratio ( 27846281) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Iron levels ( 19880490) Iron status biomarkers ( 19820699 19084217 21149283 21208937) Iron status biomarkers (ferritin levels) ( 33536631 28334935 25352340) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) LDL cholesterol ( 30275531) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 19862010 28453575 29403010 23263863 19853236 28031487 27863252 28017375 20139978 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494 28453575 23263863 27863252 28017375 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 28017375 19862010 19853236 31194788 20139978 29403010 28453575) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 20927387 23222517 23935956) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731)
Novel Interacting Genes		4 novel interacting genes: CFTR COL1A1 FN1 LAMA1
Interacting Genes		4 interacting genes: CFTR COL1A1 FN1 LAMA1
Entrez ID		164656
HPRD ID		10270
Ensembl ID		ENSG00000187045
Uniprot IDs		Q8IU80
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Positive Regulation Of Developmental Process Extracellular Matrix Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To CAMP Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cellular Response To Vitamin E Protease Binding Basement Membrane Response To Purine-containing Compound Positive Regulation Of Anion Channel Activity Anatomical Structure Formation Involved In Morphogenesis Regulation Of Developmental Process Collagen Type I Trimer Regulation Of Cell Adhesion Cellular Response To Fluoride Positive Regulation Of Monoatomic Anion Transport Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Laminin-1 Complex Laminin-3 Complex Regulation Of Multicellular Organismal Process Cellular Developmental Process Positive Regulation Of Enamel Mineralization Regulation Of Cell Motility Regulation Of Locomotion Response To Fluoride Calcium-independent Cell-matrix Adhesion Laminin Complex Regulation Of Cell-substrate Adhesion Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Intramembranous Ossification Neural Crest Cell Migration Involved In Autonomic Nervous System Development Retinal Blood Vessel Morphogenesis Glycosphingolipid Binding Regulation Of Cell Communication Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Signaling Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Vitamin E Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation
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