AKR1C2

Description		aldo-keto reductase family 1 member C2
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carboxylic Acid Binding Bile Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Digestion Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs		NADH Ursodeoxycholic acid Nicotinamide adenine dinucleotide phosphate Chenodeoxycholic acid Epitestosterone
Diseases
GWAS		Height ( 28552196) Hip index ( 34021172) Longevity ( 26912274) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: LAMTOR5
Interacting Genes		1 interacting genes: LAMTOR5
Entrez ID		1646
HPRD ID		11857
Ensembl ID		ENSG00000151632
Uniprot IDs		B4DK69 P52895
PDB IDs		1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7
Enriched GO Terms of Interacting Partners?		FNIP-folliculin RagC/D GAP Ragulator Complex Protein Localization To Lysosome Regulation Of Interleukin-8 Production Positive Regulation Of TOR Signaling Protein Localization To Vacuole Positive Regulation Of TORC1 Signaling Regulation Of Cell Size Regulation Of TORC1 Signaling Viral Genome Replication TOR Signaling Positive Regulation Of Protein Localization To Nucleus Cellular Response To Amino Acid Stimulus TORC1 Signaling Positive Regulation Of Interleukin-8 Production Response To Amino Acid Regulation Of TOR Signaling Late Endosome Membrane Viral Process Regulation Of Protein Localization To Nucleus Molecular Adaptor Activity
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