DDC

Description		dopa decarboxylase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Aromatic-L-amino-acid Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Enzyme Binding Pyridoxal Phosphate Binding 5-hydroxy-L-tryptophan Decarboxylase Activity L-dopa Decarboxylase Activity
	Biological Process	Kidney Development Amino Acid Metabolic Process Catecholamine Metabolic Process Response To Toxic Substance Gene Expression Carboxylic Acid Metabolic Process Biogenic Amine Biosynthetic Process Dopamine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process
Pathways		Catecholamine biosynthesis Serotonin and melatonin biosynthesis
Drugs		Pyridoxal phosphate Carbidopa Methyldopa Benserazide
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603 22076464 23512250) Adult body size ( 32376654) Body mass index ( 25673413 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Malaria ( 19465909) Morning person ( 30696823) Schizophrenia (treatment resistant) ( 25223841) Serum metabolite levels ( 33031748)
Novel Interacting Genes		3 novel interacting genes: AR ATF6 RELA
Interacting Genes		3 interacting genes: AR ATF6 RELA
Entrez ID		1644
HPRD ID		00145
Ensembl ID		ENSG00000132437
Uniprot IDs		A0A087WU57 A0A087WV24 A0A0S2Z3N4 P20711 Q53Y41
PDB IDs		3RBF 3RBL 3RCH 8OR9 8ORA
Enriched GO Terms of Interacting Partners?		Transcription Cis-regulatory Region Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Enzyme Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Prostate Induction RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Male Somatic Sex Determination Positive Regulation Of ATF6-mediated Unfolded Protein Response Hormone-mediated Signaling Pathway Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis NF-kappaB P50/p65 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Male Genitalia Morphogenesis POU Domain Binding Negative Regulation Of Apoptotic Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Ketone Animal Organ Development Intracellular Receptor Signaling Pathway Response To Steroid Hormone Positive Regulation Of Integrin Biosynthetic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Cobalamin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Signal Transduction Androgen Binding Postsynapse To Nucleus Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication
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