CYP27A1

Description		cytochrome P450 family 27 subfamily A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Metal Ion Binding Cholestanetetraol 26-dehydrogenase Activity
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Small Molecule Biosynthetic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes CTX
Drugs
Diseases		Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Novel Interacting Genes		3 novel interacting genes: DCP2 MTDH PRDX4
Interacting Genes		3 interacting genes: DCP2 MTDH PRDX4
Entrez ID		1593
HPRD ID		05939
Ensembl ID		ENSG00000135929
Uniprot IDs		Q02318
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Intercellular Canaliculus RNA Exonuclease Activity, Producing 5'-phosphomonoesters 5'-3' RNA Exonuclease Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Regulation Of Telomerase RNA Localization To Cajal Body Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Molecular Sequestering Activity Positive Regulation Of Catabolic Process MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Hydrogen Peroxide Catabolic Process RNA Decapping Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Antioxidant Activity Histone MRNA Metabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process NF-kappaB Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Telomere Maintenance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cell Redox Homeostasis Regulation Of Telomere Maintenance Via Telomerase
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