CYP2A6

Description		cytochrome P450 family 2 subfamily A member 6
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Coumarin 7-hydroxylase Activity Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Coumarin Catabolic Process
Pathways		Xenobiotics CYP2E1 reactions
Drugs		Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33339817 29403010) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872) Chronic obstructive pulmonary disease ( 22080838 28166215) Chronotype ( 30696823) Coffee consumption ( 31046077) Liver enzyme levels (alanine transaminase) ( 33972514) Local histogram emphysema pattern ( 25006744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 33144568) Nicotine metabolite ratio in current smokers ( 27488534 26407342 28921760) Non-small cell lung cancer ( 31326317) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33339817 33547301) Smoking behavior ( 20418888 23049750 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 31089300 30679032 30617275) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Squamous cell lung carcinoma ( 28604730) Urinary sodium excretion ( 31409800)
Novel Interacting Genes		2 novel interacting genes: CYB5A POR
Interacting Genes		2 interacting genes: CYB5A POR
Entrez ID		1548
HPRD ID		00420
Ensembl ID		ENSG00000255974
Uniprot IDs		P11509
PDB IDs		1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
Enriched GO Terms of Interacting Partners?		Intracellular Membrane-bounded Organelle Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Enzyme Binding Positive Regulation Of Steroid Hormone Biosynthetic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Positive Regulation Of Hormone Biosynthetic Process Demethylation Flavonoid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Response To Follicle-stimulating Hormone FMN Binding Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Response To Gonadotropin Endoplasmic Reticulum Membrane Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process NADP Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Steroid Metabolic Process Response To Dexamethasone Regulation Of Chondrocyte Differentiation Electron Transfer Activity Flavin Adenine Dinucleotide Binding Endoplasmic Reticulum Regulation Of Cartilage Development Enzyme Activator Activity Fatty Acid Oxidation Regulation Of Steroid Biosynthetic Process Lipid Oxidation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Electron Transport Chain Regulation Of Steroid Metabolic Process Xenobiotic Metabolic Process
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