IRX2

Description		iroquois homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Cell Development Specification Of Loop Of Henle Identity Proximal/distal Pattern Formation Involved In Metanephric Nephron Development
Pathways		Nephron development
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Body mass index (adult) ( 28430825) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Toenail selenium levels ( 25343990)
Novel Interacting Genes		3 novel interacting genes: PFDN5 PLAGL2 TLE5
Interacting Genes		3 interacting genes: PFDN5 PLAGL2 TLE5
Entrez ID		153572
HPRD ID		09368
Ensembl ID		ENSG00000170561
Uniprot IDs		Q9BZI1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Wnt Signaling Pathway RNA Polymerase II Core Complex Assembly Transcription Corepressor Activity Chylomicron Assembly Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Anoikis Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Amyloid Fibril Formation Plasma Lipoprotein Particle Assembly Regulation Of Anoikis Protein-lipid Complex Assembly Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process
Tagcloud ?