CTRB1

Description		chymotrypsinogen B1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Digestion
Pathways		Activation of Matrix Metalloproteinases Uptake of dietary cobalamins into enterocytes
Drugs		Trans-O-Hydroxy-Alpha-Methyl Cinnamate 2,4-Dihydroxy-Trans Cinnamic Acid Phenylethane Boronic Acid Phosphorylisopropane Aprotinin 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acid 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE (2S) N-acetyl-L-alanyl-αL-phenylalanyl-chloroethylketone 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Phenylalanylmethylchloride L-1-naphthyl-2-acetamido-ethane boronic acid D-1-naphthyl-2-acetamido-ethane boronic acid D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Pancreatic cancer ( 25086665) Type 2 diabetes ( 30054458)
Novel Interacting Genes		4 novel interacting genes: LYPD3 SERPINA1 SERPINA3 SERPINF2
Interacting Genes		4 interacting genes: LYPD3 SERPINA1 SERPINA3 SERPINF2
Entrez ID		1504
HPRD ID		00345
Ensembl ID		ENSG00000168925
Uniprot IDs		P17538
PDB IDs
Enriched GO Terms of Interacting Partners?		Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Extracellular Space Inflammatory Response Extracellular Region Protease Binding Blood Microparticle Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Body Fluid Levels Negative Regulation Of Plasminogen Activation Defense Response Fibrinogen Complex Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Fibrinolysis Maintenance Of Gastrointestinal Epithelium Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Collagen Biosynthetic Process Laminin Binding Negative Regulation Of Smooth Muscle Cell Apoptotic Process Extracellular Exosome Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Epithelial Structure Maintenance COPII-coated ER To Golgi Transport Vesicle Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Endopeptidase Inhibitor Activity
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