TMC8

Description		transmembrane channel like 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Protein Binding Mechanosensitive Monoatomic Ion Channel Activity Tumor Necrosis Factor Binding Protein Sequestering Activity
	Biological Process	Intracellular Zinc Ion Homeostasis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Stabilization Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Drugs
Diseases		Epidermodysplasia verruciformis
GWAS		Glycated hemoglobin levels ( 29170429) hemolysis of donated blood (cold-storage) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Novel Interacting Genes		1 novel interacting genes: TRADD
Interacting Genes		1 interacting genes: TRADD
Entrez ID		147138
HPRD ID		08387
Ensembl ID		ENSG00000167895
Uniprot IDs		B3KXZ8 Q8IU68
PDB IDs
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Hair Follicle Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Hair Follicle Development Regulation Of Hair Cycle Non-canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Extrinsic Apoptotic Signaling Pathway Kinase Binding Cytoplasmic Side Of Plasma Membrane Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Positive Regulation Of Inflammatory Response Receptor Complex Molecular Adaptor Activity Protein-macromolecule Adaptor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction
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