PIK3R6

Description		phosphoinositide-3-kinase regulatory subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Angiogenesis Immune Response G Protein-coupled Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of MAP Kinase Activity Positive Regulation Of T Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Co-stimulation by ICOS
Drugs
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: DNAH2 PIK3CG
Interacting Genes		2 interacting genes: DNAH2 PIK3CG
Entrez ID		146850
HPRD ID		12682
Ensembl ID		ENSG00000276231
Uniprot IDs		B3KRK9 Q5UE93
PDB IDs
Enriched GO Terms of Interacting Partners?		Hepatocyte Apoptotic Process 1-phosphatidylinositol-3-kinase Activity Natural Killer Cell Chemotaxis Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Cardiac Muscle Contraction Secretory Granule Localization Phosphatidylinositol 3-kinase Complex, Class IB Dendritic Cell Migration Negative Regulation Of Blood Circulation Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Rac Protein Signal Transduction Respiratory Burst Involved In Defense Response Phosphatidylinositol-3-phosphate Biosynthetic Process Dendritic Cell Chemotaxis Phosphatidylinositol-mediated Signaling T Cell Chemotaxis Negative Regulation Of Muscle Contraction Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process Respiratory Burst 1-phosphatidylinositol-4-phosphate 3-kinase Activity Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Triglyceride Metabolic Process Mast Cell Degranulation Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Heart Contraction Sphingosine-1-phosphate Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Lymphocyte Chemotaxis 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Sphingolipid Mediated Signaling Pathway Negative Regulation Of Lipid Catabolic Process Neutrophil Extravasation Cellular Extravasation Inner Dynein Arm Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Axonemal Dynein Complex Dynein Light Intermediate Chain Binding Ephrin Receptor Binding Positive Regulation Of MAP Kinase Activity Regulation Of Rac Protein Signal Transduction Cell Motility T Cell Migration 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Leukocyte Degranulation Regulation Of Triglyceride Metabolic Process
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