RAD9B

Description		RAD9 checkpoint clamp component B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function	Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS
Novel Interacting Genes		5 novel interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A
Interacting Genes		5 interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A
Entrez ID		144715
HPRD ID		12221
Ensembl ID		ENSG00000151164
Uniprot IDs		B4DX60 B4DYM6 J3KPN7 Q6WBX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex DNA Replication Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Repair Meiotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Double-stranded DNA 3'-5' DNA Exonuclease Activity Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide-excision Repair Response To Radiation Response To Stress Rad17 RFC-like Complex Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Meiotic Recombination Checkpoint Signaling Signal Transduction Nucleolus Double-strand Break Repair Macromolecule Metabolic Process
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