CS

Description		citrate synthase
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	RNA Binding Transferase Activity Citrate Synthase Activity Identical Protein Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Trifluoroacetonyl coenzyme A Coenzyme A Oxaloacetate Ion alpha-Fluoro-carboxymethyldethia coenzyme A complex D-Malic acid Nitromethyldethia coenzyme A Citric acid
Diseases
GWAS		Height ( 23456168 31562340 34270706) Inflammatory skin disease ( 25574825) Refractive error ( 32231278)
Novel Interacting Genes		9 novel interacting genes: AGPS CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LCOR LINC01554 MDH2
Interacting Genes		9 interacting genes: AGPS CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LCOR LINC01554 MDH2
Entrez ID		1431
HPRD ID		00349
Ensembl ID		ENSG00000062485
Uniprot IDs		O75390
PDB IDs		5UZP 5UZQ 5UZR
Enriched GO Terms of Interacting Partners?		Protein Refolding Tubulin Complex Assembly Response To Heat Unfolded Protein Binding Contractile Muscle Fiber Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Response To Temperature Stimulus Apoptotic Process Involved In Development Protein Folding Lens Development In Camera-type Eye Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Microtubule-based Process Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Protein Kinase C Signaling Axon Cytoplasm L-malate Dehydrogenase (NADP+) Activity Alkylglycerone-phosphate Synthase Activity Mitochondrion Camera-type Eye Development Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Response To Hydrogen Peroxide Response To Estradiol Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Protein Kinase C Inhibitor Activity L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Eye Development Regulation Of Cellular Localization Z Disc Mitochondrial RNA 5'-end Processing Isoleucine Metabolic Process L-isoleucine Catabolic Process Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species TRNA Methyltransferase Complex
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