SAMD8

Description		sterile alpha motif domain containing 8
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Novel Interacting Genes		3 novel interacting genes: TGFBR1 USP54 ZNF503
Interacting Genes		3 interacting genes: TGFBR1 USP54 ZNF503
Entrez ID		142891
HPRD ID		18014
Ensembl ID		ENSG00000156671
Uniprot IDs		Q96LT4 V9HVY4
PDB IDs		8IJQ 8IJR 8W9W 8W9Y
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Extracellular Matrix Assembly Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endothelial Cell Activation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex G1 To G0 Transition Involved In Cell Differentiation Coronary Vasculature Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Ventricular Trabecula Myocardium Morphogenesis G1 To G0 Transition I-SMAD Binding K63-linked Deubiquitinase Activity Pharyngeal System Development Heart Trabecula Morphogenesis Transforming Growth Factor Beta Binding Serine/threonine Protein Kinase Complex Regulation Of Extracellular Matrix Assembly Filopodium Assembly Negative Regulation Of Cell Population Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Response To Cholesterol Positive Regulation Of Filopodium Assembly Cell Population Proliferation Negative Regulation Of Chondrocyte Differentiation Blastocyst Development Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cartilage Development Endothelial Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation
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