CPE

Description		carboxypeptidase E
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Endomembrane System Membrane Transport Vesicle Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Neurexin Family Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Proteolysis Peptide Metabolic Process Cell Communication Neuropeptide Signaling Pathway Intracellular Protein Localization Wnt Signaling Pathway Protein Processing Signaling Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Modification Process Protein Localization To Membrane
Pathways		Insulin processing
Drugs		Insulin human
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		18 novel interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Interacting Genes		18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		1363
HPRD ID		00272
Ensembl ID		ENSG00000109472
Uniprot IDs		A0A384N679 P16870
PDB IDs
Enriched GO Terms of Interacting Partners?		Hormone Activity Feeding Behavior Receptor Ligand Activity Axolemma G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cell Junction Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Hormone Activity Eating Behavior Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Extracellular Region Positive Regulation Of Glucose Metabolic Process Regulation Of Peptide Hormone Secretion Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Neuron Recognition Thyrotropin-releasing Hormone Activity
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