COL11A2

Description		collagen type XI alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Skeletal System Development Sensory Perception Of Sound Collagen Fibril Organization Cartilage Development Roof Of Mouth Development Soft Palate Development
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Deafness, autosomal recessive Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Deafness, autosomal dominant Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sjögren's syndrome ( 24097066) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775)
Novel Interacting Genes		4 novel interacting genes: ANXA7 DAXX PIN1 TK1
Interacting Genes		4 interacting genes: ANXA7 DAXX PIN1 TK1
Entrez ID		1302
HPRD ID		00376
Ensembl ID		ENSG00000204248
Uniprot IDs		A0A0C4DFS1 A0A0G2JL35 A0A0G2JL78 A0A140TA43 P13942 Q4VXY6
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cis-trans Isomerase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite Protein-containing Complex Assembly Phosphoserine Residue Binding Thymidine Metabolic Process Thymidine Biosynthetic Process Chromaffin Granule Membrane Response To Metal Ion Protein-containing Complex Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Response To Phorbol 13-acetate 12-myristate Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Cellular Response To Arsenic-containing Substance Cellular Response To Unfolded Protein Cellular Response To Cadmium Ion Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Androgen Receptor Signaling Pathway Microtubule Polymerization Cellular Response To Copper Ion Nuclear Androgen Receptor Binding Cellular Response To Topologically Incorrect Protein Response To Salt Response To Arsenic-containing Substance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Protein Targeting To Mitochondrion Postsynaptic Cytosol Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Amyloid-beta Formation
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