COL4A3

Description		collagen type IV alpha 3 chain
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 29760442 31798171 32528159) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Novel Interacting Genes		17 novel interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Interacting Genes		17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		1285
HPRD ID		00354
Ensembl ID		ENSG00000169031
Uniprot IDs		Q01955
PDB IDs		5NB0 6WKU
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion
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