IQGAP3

Description		IQ motif containing GTPase activating protein 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction Cell Cortex Lateral Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Calmodulin Binding Small GTPase Binding Actin Filament Binding Myosin VI Light Chain Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ras Protein Signal Transduction Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways		RHO GTPases activate IQGAPs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Creatine kinase levels ( 29403010)
Novel Interacting Genes		3 novel interacting genes: CALM2 CCDC198 UBC
Interacting Genes		3 interacting genes: CALM2 CCDC198 UBC
Entrez ID		128239
HPRD ID		11051
Ensembl ID		ENSG00000183856
Uniprot IDs		Q86VI3
PDB IDs		3ISU
Enriched GO Terms of Interacting Partners?		Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Vesicle Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Sequestering Of Calcium Ion Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Tag Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcineurin-mediated Signaling Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Presynaptic Endocytosis Spindle Microtubule Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Sarcomere Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Energy Homeostasis Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Regulation Of Monoatomic Ion Transmembrane Transporter Activity Endocytic Vesicle Membrane
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