CNR1

Description		cannabinoid receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Actin Cytoskeleton Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Membrane Raft Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonal Fasciculation Cannabinoid Signaling Pathway Glucose Homeostasis Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Dronabinol Nabilone Ricinoleic acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Novel Interacting Genes		10 novel interacting genes: ADORA2A BECN2 GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Interacting Genes		10 interacting genes: ADORA2A BECN2 GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		1268
HPRD ID		00259
Ensembl ID		ENSG00000118432
Uniprot IDs		P21554 S5TLS4 V5KA96
PDB IDs		1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B 7FEE 7V3Z 7WV9 8GAG 8GHV 8IKG 8IKH 8K8J 8WRZ 8WU1 9B54 9B65 9B9Y 9B9Z 9BA0 9ERX
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Urine Volume Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Neuropeptide Signaling Pathway GTP Binding Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Secretion By Cell Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Postsynaptic Signal Transduction Regulation Of Protein Secretion Signal Transduction Regulation Of ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Hepatocyte Growth Factor Receptor Activity Plasma Membrane Ciliary Basal Body Regulation Of Cell Communication Regulation Of Signaling GDP Binding Feeding Behavior G Protein-coupled Receptor Activity Orexin Receptor Activity G Protein-coupled Receptor Catabolic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Protein Transport Positive Regulation Of Acetylcholine Secretion, Neurotransmission Nucleotide Binding D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Cell Division Positive Regulation Of MAPK Cascade Regulation Of Acetylcholine Secretion, Neurotransmission Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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